Hindi Episode 1.21
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Continuing our survey before the Rus with a look at the eastern part of the region. The Bulgars reach the central Volga, Magyars move south, Khazar power preventing new incursions from the steppe starts to crumble.Read the episode blog post: -121-before-the-rus-part-ii-bulgars-chuvash-pechenegs-magyarsSupport this podcast and get access to exclusive member episodes by subscribing through Patreon, Anchor, or Apple Podcasts.
The inherited form of factor X deficiency, known as congenital factor X deficiency, is caused by mutations in the F10 gene, which provides instructions for making a protein called coagulation factor X. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury. Some F10 gene mutations that cause factor X deficiency reduce the amount of coagulation factor X in the bloodstream, resulting in a form of the disorder called type I. Other F10 gene mutations result in the production of a coagulation factor X protein with impaired function, leading to type II factor X deficiency. Reduced quantity or function of coagulation factor X prevents blood from clotting normally, causing episodes of abnormal bleeding that can be severe.
The Centers for Disease Control and Prevention (CDC) does not recommend HSV IgM testing because it cannot differentiate between herpes simplex virus type 1 (the type commonly associated with oral herpes) and herpes simplex virus type 2 (the type more commonly linked to genital herpes). The test might also deliver a positive result during a recurrent oral or genital herpes episode.
In 2004, a Dutch dub of Blue's Clues premiered on Nickelodeon in The Netherlands, known as "Blue's Clues". The majority of the cast has been found here, alongside eleven episodes that were posted to Google Photos as well as Season 1 being available on Noggin, although you will need an Apple Tv subscription. The dub last aired in 2013 on Nick Jr.
On November 2008, a Tagalog dub of Blue's Clues premiered on TV5. The majority of the cast is unknown and episodes have not surfaced; only the intro survives. The dub last aired in July 2, 2010.
On January 17, 2019, the first episode was uploaded to the Internet Archive. On February 2021, the nineteenth episode was added to yesVOD for a limited time. In addition, episodes 4, 7-15, and 17-19 were added to Noggin, although an Apple TV subscription is required.
On June 5, 2022, the show began to reair on Nick Jr. but only seven episodes were aired while the eighth episode Blue Goes to the Beach had an error where it played the M&E for half the episode before switching to the next episode Pretend Time for the second half. After this the show was removed from the schedule.
In 2010, a Hungarian dub of Blue's Clues was recorded but was not released until 2020. The majority of the cast has been found here, alongside episodes 1-3,5-6 being added to Apple TV, and recently certain countries have added Hungarian audio to episodes 4,19-20 but it requires a subscription. It is unknown if this dub ever aired on television.
In 2000, an Indonesian dub of Blue's Clues premiered on ANTV in Indonesia, and were later shown on Global TV, Lativi, and Nick Jr. Two episodes were posted on Instagram here and here also Season 1 was added to Noggin but you need an Apple TV subscription. It is currently unknown when the dub last aired.
In 2004, a Japanese dub of Blue's Clues premiered on Nickelodeon in Japan. The dub aired until 2009 when Nickelodeon Japan shut down. It was not until 2018, when the dub reaired on the newly rebooted Nickelodeon Japan. Only 26 episodes have been released and are available here but according to this promo more episodes were dubbed but those episodes have not been released onto Amazon.
On an unknown date, a Malay dub of Blue's Clues premiered on TV3 in Malaysia, and was later shown on TV9. Originally one episode was uploaded to Youtube but recently Noggin added Season 1, although you will need an Apple TV subscription. It is currently unknown when the dub last aired.
In 2005, a Mandarin dub of Blue's Clues premiered on HahaNick on SMG, and was later shown on YOYO TV. Some episodes have been posted onto Youku and Season 1 (excluding episodes 1-3,5 ) have been added to Noggin although you will need an Apple TV subscription. has been It is currently unknown when the dub last aired.
In 2012, a Norwegian dub of Blue's Clues premiered on Nick Jr in Norway, known as "Blue's Clues". Only the voice of Steve has been found here. The dub used to stream on the streaming service, Viaplay. But it has since been removed from the service. Noggin added Norwegian audio to episodes 1, and 19-20 in certain countries, although you will need an Apple TV subscription. of The dub last aired in 2012 on Nick Jr.
In 2008, a Polish dub of Blue's Clues premiered on Nickelodeon in Poland,and was later aired on VH1 and Nick Jr. Episodes have been posted to Chomikuj and here apart from Season 1, where episodes 1-3,5-6 are available on Noggin in Poland where as the rest on Season 1 is available in certian countries although you need an Apple TV subscription. The dub last aired in 2012 on Nick Jr.
This dub was released on Noggin with only episodes 1-5,19-20 (4,19-20 being available in certain countries) having Romanian audio although you will need an Apple TV subscription . It is currently unknown when this dub was released or if it ever aired on television.
In 1999 , the European Spanish dub of Blue's Clues premiered on Nickelodeon, known as "Las Pistas de Blue". The cast from this dub can be found here. Most episodes from the first four seasons are available on Pluto TV Spain. It is currently unknown when the dub last aired on TV.
In 2010, a Swedish dub of Blue's Clues premiered on Nick Jr in Sweden. The majority of the cast is unknown and episodes have not surfaced. The dub last aired in 2012 on Nick Jr. Noggin added Swedish audio to episodes 1, and 19-20 in certain countries, although you will need an Apple TV subscription.
On an unknown date, a Thai dub of Blue's Clues premiered on True Spark. The majority of the cast has been identified and can be found here. It is currently unknown when the dub last aired. For awhile episode 1 of the Thai dub had been available on Noggin in Thailand, but the show has since been removed. However, episodes 1, 19, and 20 are available in other countries, although you will need an Apple TV subscription.
The eight-episode psychological thriller follows Alice, a 48-year-old film director who becomes obsessed with a 24-year-old screenwriter. The show is said to explore themes like jealousy, guilt, fear and aging.
For all genotypes, the morbidity of the disease is the driving factor in pursuing a HSCT. Preventative HSCT should be considered for children with higher-risk genotypes, HbSS, and HbSβ0. HSCT for adults with SCD is better tolerated with a low-intensity regimen, with the caveat of requiring prolonged immune suppression to maintain mixed-donor chimerism. AVN, avascular necrosis; TCD, transcranial Doppler; VOE, veno-occlusive episodes. *Especially in children with difficult access to adequate lifelong supportive medical care, we recommend reviewing statistics for OS, DFS, GR, and GVHD with families as they weigh these options. (King & Shenoy, 2014)
For the survival outcome, median follow-up was 33 months (range, 12 - 76 months). The five-year estimated disease-free survival was 51% (95% ci, 38% - 64%) and the five-year overall survival was 67% (95% CI, 55% - 79%). In the multivariate analysis, mismatched HLA donor (HR = 2.39; 95% CI, 1.22 - 4.69; p = 0.01) and a high-risk Lille score (HR = 5.37; 95% CI, 1.58 - 18.24; p = 0.007) were risk factors for disease-free survival. Age greater than 55 years (HR = 2.70; 95% CI, 1.21 - 6.03; p = 0.02) and mismatched HLA donor (HR = 2.70; 95% CI, 1.21 - 6.03; p = 0.006) were significant risk factors for overall survival. Nonrelapse mortality at one year was 16% (95% CI, 9% - 23%). The cumulative incidence of relapse at five years was 29% (95% CI, 16% - 42%). In the multivariate analysis, a high-risk Lille score was a significant factor for higher incidence of relapse (HR = 5.23; 95% CI, 1.14 - 24.01; p = 0.003). Twenty-seven percent of transplanted patients developed grade II - IV acute GVHD; 11% developed grade III - IV acute GVHD. Forty-nine percent of patients developed chronic GVHD (limited disease in 24% and extensive disease in 24%).
Engraftment was successful in all but one patient (n = 86). There were six transplantation-related deaths. The estimated five-year TRM rate was 6.9%. Overall EFS at five years was 86.1%. Median follow-up of suvivors was six years (range, 1.6 - 17.5 years). At the time the results were published, 81 patients were alive with a mean age of 16.2 years (range, 6.1 - 28 years). Seventy-nine patients did not experience vaso-occlusive crises or acute chest syndrome episodes, and they had not been given transfusions since engraftment. Seventeen of 86 assessable patients (20%) developed grade II or higher acute GVHD. The incidence of acute GVHD was significantly higher in patients older than 15 years (p = 0.003) and in patients transplanted with HLA-mismatched stem cells (p = 0.007). A mild form of chronic GVHD occurred in nine of 83 (11%) assessable patients and an extensive form occurred in two of 83 (2.4%) patients.
Bernaudin et al. (2007) analyzed data from 87 children in France who received an alloSCT in 14 centers during a 16 year timespan (1988 to 2004); the last of which was performed 11 years ago. There was variability in the patient population and treatment regimens due to the long timespan and the constantly evolving state of the practice of transplantation medicine. The lack of a control group for this retrospective analysis was another limitation of the study design. A reasonably long median duration of follow-up of six years with a range of 1.6 - 17.5 years was available. The estimated five-year TRM rate was 6.9%. Overall EFS at five years was 86.1%. At the time the results were published, 81 patients between the ages of six and 28 years were alive. Seventy-nine of these patients had not experienced vaso-occlusive crises or acute chest syndrome episodes and had not received blood transfusions. Twenty percent of patients developed grade II or higher acute GVHD while 2.4% suffered from extensive chronic GVHD. 2b1af7f3a8