Misra started his career as a news anchor in Hindi channels. Later he moved to London to work for BBC and later he came back to India in 1995, where he joined the NDTV. In 2008, Misra has also started hosting his own show, Neelesh Misra Show, a talk show, where he interviews various personalities, from politics, entertainment, to public life. He also hosts the news magazine Neelesh Misra News.
Misra hosted the Indian version of the youth segment of the British show Strictly Come Dancing in 2013, for its Indian audience. He has also hosted the Indian version of Britain's Got Talent. He hosted the 16th season of the Indian version of Dancing with the Stars in 2013 and the 10th season of the Indian version of Britain's Got Talent in 2014. 827ec27edc