- age>18 years- history of poorly controlled type 2 diabetes mellitus (HbA1c>9% and/or self-reported hypoglycemia) and/or use of oral antidiabetic drugs and/or insulin- but on no other glucose-lowering medications- no major modifications in diabetes treatment within 30 days preceding the study- no evidence of hypoglycemia unawareness (measured with a GSRS question which was not used in the trial)- no history of DKA in previous 6 months or any documented episode of severe hypoglycemia (confirmed by medical history) in the last 2 years- no non-compliance with oral antidiabetic treatment in the previous 6 months- able to understand and provide written informed consent- provided with a report of their medical history, signs, symptoms, and concomitant diseases/medications- provided with a copy of the informed consent form and the Declaration of the Helsinki and its amendments- had no history of pancreatitis
There were 10 subjects, 9 males, mean age 65.8±12.1 years, weight 81.3±14.2 kg, body mass index (BMI) 27.3±3.4 kg/m2. There were no major changes in diabetes treatment in the last 2 months. The patients had a mean HbA1c of 10.2±2.1% (68.
- open-label, single-arm, single-dose study (PLANET) - 15-day treatment period in which each patient was instructed to intake a dose of sitagliptin 100 mg orally and blood glucose was measured before and 1, 2, 3, 4, and 5 h after the intake. - patients were recruited in the same way as in the previous PLANT study.
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